Method for preparation of aluminum hydroxyphosphate adjuvant
US9573811B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 19, 2012 |
| Grant date | Feb 21, 2017 |
| Priority date | — |
| Expiry date | Jan 10, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods for preparing amorphous aluminum hydroxyphosphate. An aluminum salt and a phosphate solution are co-mixed at a constant ratio in the presence of a buffer. Preferably, an excess of the phosphate solution is used to act as a buffer. Due to the presence of a buffer, the pH is maintained constant during reaction (after initial rapid equilibration) without active adjustment. The methods are particularly applicable for the large scale manufacturing of aluminum phosphate adjuvant. Aluminum phosphate is used as an adjuvant in vaccine formulations, particularly those including a protein or saccharide antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.