Regioselective N-2 arylation of indazoles
US9580407B2 · kind B2 · utility
4Cited by
2References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 3, 2013 |
| Grant date | Feb 28, 2017 |
| Priority date | — |
| Expiry date | Dec 3, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I:comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.