Inhibitors of focal adhesion kinase

US9580439B2 · kind B2 · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Congxin Liang · North Palm Beach, US
• Marcel Koenig · Burlingame, US
• Yuanjun He · North Palm Beach, US
• Pär Holmberg · Bodafors, SE

Key dates

• Filing date: Jun 19, 2013
• Grant date: Feb 28, 2017
• Expiry date: Jun 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.