Compositions and methods for the diagnosis and treatment of tumor

US9580514B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Sunil Bhakta · Hayward, US
• Meredith Hazen · South San Francisco, US
• Jo-Anne Hongo · Redwood City, US
• Jagath Reddy Junutula · Fremont, US
• Isidro Hotzel · Brisbane, US
• Yonglei Shang · Millbrae, US
• Shang-Fan Yu · Millbrae, US

Key dates

• Filing date: Mar 14, 2013
• Grant date: Feb 28, 2017
• Expiry date: Mar 14, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.