Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels

US9586968B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Mark E. Layton · Harleysville, US
• Anthony J. Roecker · Harleysville, US
• Melissa Egbertson · Ambler, US
• Kristen L. G. Jones · Oreland, US
• Dansu Li · New York, US
• Xiu Wang · Shanghai, CN
• Xuanjia Peng · Shanghai, CN

Key dates

• Filing date: Nov 24, 2014
• Grant date: Mar 7, 2017
• Expiry date: Nov 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.