Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase

US9593136B2 · kind B2 · utility

Assignees

• The George Washington University · US
• George Mason University · US
• St. Jude Children's Research Hospital, Inc. · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Helena I. Boshoff · Potomac, US
• Cynthia Dowd · Washington, US
• Emily R. Jackson · Springfield, US
• Kylene Kehn-Hall · Fredericksburg, US
• Richard E. Lee · Cordova, US
• Robin Lee · Honolulu, US
• Geraldine San Jose · Gujan-Mestras, FR

Key dates

• Filing date: Jun 29, 2012
• Grant date: Mar 14, 2017
• Expiry date: Jun 29, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II)