Inhibitors of the renal outer medullary potassium channel

US9604998B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Alexander Pasternak · Brookline, US
• Reynalda K. DeJesus · East Brunswick Township, US
• Fa-Xiang Ding · Staten Island, US
• Shuzhi Dong · Plainsboro, US
• Jessica Frie · Harleysville, US
• Xin Gu · Scotch Plains, US
• Jinlong Jiang · Scotch Plains, US
• Aurash Shahripour · Rahway, US
• Barbara Pio · West Orange, US
• Haifeng Tang · South San Francisco, US
• Shawn P. Walsh · Bound Brook, US

Key dates

• Filing date: Feb 12, 2014
• Grant date: Mar 28, 2017
• Expiry date: Feb 18, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.