Phenylmorpholines and analogues thereof

US9617229B2 · kind B2 · utility

Assignees

• Research Triangle Institute · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Bruce E. Blough · Raleigh, US
• Richard B. Rothman · Baltimore, US
• Antonio Landavazo · Durham, US
• Kevin M. Page · Fuquay-Varina, US
• Ann Marie DECKER · Durham, US

Key dates

• Filing date: May 20, 2011
• Grant date: Apr 11, 2017
• Expiry date: Nov 30, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compounds and prodrugs and methods of preparation of compounds and prodrugs that are capable of functioning as releasers and/or uptake inhibitors of one or more monoamine neurotransmitters, including dopamine, serotonin, and norepinephrine. Also provided are pharmaceutical compositions comprising one or more of these compounds or prodrugs, which may further comprise one or more additional therapeutic agents. Also provided are methods of treatment of various conditions that may be responsive to modification of monoamine neurotransmitter levels, such as pre-obesity, obesity, addiction, and depression.