Thio compounds

US9623020B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Nigel H. Greig · Phoenix, US
• Weiming Luo · Timonium, US
• David Tweedie · Joppatowne, US
• Harold W. Holloway · Middle River, US
• Qian-Sheng Yu · Timonium, US
• Edward J. Goetzl · San Francisco, US

Key dates

• Filing date: Jun 22, 2015
• Grant date: Apr 18, 2017
• Expiry date: Jun 22, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.