Artificial immune system: methods of use

US9625444B2 · kind B2 · utility

Assignees

• SANOFI PASTEUR VAXDESIGN CORPORATION · US
• THE SCRIPPS RESEARCH INSTITUTE · US
• Massachusetts Institute of Technology · US
• Whitehead Institute For Biomedical Research · US
• Mount Sinai School of Medicine of New York University · US

Inventors

• William L. Warren · Orlando, US
• Heather Fahlenkamp · Cleveland, US
• Russell Higbee · Orlando, US
• Anatoly Kachurin · Orlando, US
• Conan Li · Los Altos, US
• Mike Nguyen · Orlando, US
• Robert Parkhill · Orlando, US
• Guzman Sanchez-Schmitz · Orlando, US
• Darrell J. Irvine · Arlington, US
• Gwendalyn J. Randolph · New York, US
• Nir Hacohen · Cambridge, US
• Bruce Torbett · Encinitas, US

Key dates

• Filing date: Mar 20, 2014
• Grant date: Apr 18, 2017
• Expiry date: Oct 15, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.