Patent · US Active

Immunoglobulin purification

US9631008B2 · kind B2 · utility

0Cited by

7References

3Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Marc Pompiati · Penzberg, DE
Andreas Schaubmar · Penzberg, DE

Key dates

Filing date	Dec 18, 2009
Grant date	Apr 25, 2017
Priority date	—
Expiry date	Nov 9, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/2866
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5. In one embodiment the anion exchange chromatography material is a membrane anion exchange chromatography material.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.