Production of heteromultimeric proteins

US9637557B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Justin Scheer · San Francisco, US
• Christoph Spiess · South San Francisco, US
• Daniel Yansura · Pacifica, US

Key dates

• Filing date: Apr 22, 2011
• Grant date: May 2, 2017
• Expiry date: Mar 23, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.