Indole derivatives useful as anti-diabetic agents

US9650375B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• John J. Acton, III · Cranford, US
• Rajan Anand · Wilmington, US
• Ashok Arasappan · Bound Brook, US
• Qun Dang · Westfield, US
• Iyassu Sebhat · Jersey City, US
• Zhifa Pu · Shanghai, CN
• Takao Suzuki · Shanghai, CN

Key dates

• Filing date: Mar 10, 2014
• Grant date: May 16, 2017
• Expiry date: Mar 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.