Patent · US Active

Malaria antigen screening method

US9651543B2 · kind B2 · utility

0Cited by

32References

6Claims

0Family size

Assignee

United States of America as represented by the Secretary of the Air Force · US

Inventors

Joseph T. Bruder · Urbana, US
Imre Kovesdi · Rockville, US
Duncan McVey · Derwood, US
Douglas E. Brough · Olney, US
C. Richter King · Washington, US
Denise Louise Doolan · Brisbane, AU
Joao Carlos Aguair · Potomac, US
Daniel John Carucci · Washington, US
Martha Sedegah · Gaithersburg, US
Walter R. Weiss · Bethesda, US
Keith Limbach · Troy, US

Key dates

Filing date	Apr 19, 2013
Grant date	May 16, 2017
Priority date	—
Expiry date	Feb 7, 2034

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.