Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

US9657015B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Christian Gnamm · Biberach an der Riß, DE
• Ralf Anderskewitz · Laupheim, DE
• Holger Hoesch · Biberach an der Riß, DE
• Gerd Morschhaeuser · Biberach, DE
• Thorsten Oost · Biberach an der Riß, DE
• Stefan Peters · Biberach an der Riß, DE
• Uwe Ries · Biberach an der Riß, DE

Key dates

• Filing date: Jul 27, 2015
• Grant date: May 23, 2017
• Expiry date: Jul 27, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted bicyclic dihydropyrimidinones of formula 1which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD. Exemplary is