Patent · US Active

Optimized Fc variants

US9657106B2 · kind B2 · utility

8Cited by

51References

16Claims

0Family size

Assignee

Xencor, Inc. · US

Inventors

Gregory Alan Lazar · Los Angeles, US
Wei Dang · Pasadena, US
John Desjarlais · Pasadena, US
Sher Bahadur Karki · Pasadena, US
Omid Vafa · Monrovia, US
Robert Hayes · Paoli, US
Jost Vielmetter · Altadena, US

Key dates

Filing date	Oct 6, 2014
Grant date	May 23, 2017
Priority date	—
Expiry date	Oct 6, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.