Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

US9663521B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• University of Kansas · US
• Northwestern University · US

Inventors

• Kevin Frankowski · Lawrence, US
• Samarjit Patnaik · Gaithersburg, US
• Sui Huang · Chicago, US
• Juan Jose Marugan · Gaithersburg, US
• John Norton · San Diego, US
• Frank J. Schoenen · Lawrence, US
• Noel Terrence Southall · Bethesda, US
• Steven Titus · Elkridge, US
• Wei Zheng · Rockville, US

Key dates

• Filing date: Dec 17, 2012
• Grant date: May 30, 2017
• Expiry date: Dec 17, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.