Isoindolinone inhibitors of phosphatidylinositol 3-kinase

US9676759B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Alex Aronov · Newton, US
• Jon Come · Cambridge, US
• Robert J. Davies · Arlington, US
• Albert Pierce · Cambridge, US
• Philip Collier · Arlington, US
• Ronald Grey, Jr. · Mansfield, US
• Hardwin O'Dowd · Boston, US
• James A. Henderson · Cambridge, US
• Elaine B. Krueger · Cambridge, US
• Anne-Laure Grillot · Cambridge, US
• Arnaud Le Tiran · Chatou, FR
• Yusheng Liao · Lexington, US
• David Messersmith · Somerville, US
• Jian Wang · Newton, US
• Jingrong Cao · Newton, US
• Upul K. Bandarage · Lexington, US
• Suganthini S. Nanthakumar · Newton, US

Key dates

• Filing date: May 7, 2013
• Grant date: Jun 13, 2017
• Expiry date: May 7, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.