Biological chip hybridization system

US9677133B2 · kind B2 · utility

Assignees

• CAPITALBIO CORPORATION · CN
• TSINGHUA UNIVERSITY · CN

Inventors

• Jiaming Ye · Hangzhou City, CN
• Pinhong Wang · Beijing, CN
• Guoqing Wang · Beijing, CN
• Liqing Duan · Beijing, CN
• Kaijun Zhao · Beijing, CN
• Jinxiu Zhang · Beijing, CN
• Xiumei Song · Beijing, CN
• Dong Wang · Nanhu, CN
• Huafang Gao · Beijing, CN
• Wanli Xing · Beijing, CN

Key dates

• Filing date: Feb 10, 2012
• Grant date: Jun 13, 2017
• Expiry date: Apr 16, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/00158
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A hybridization system is provided, which comprises a biological chip having a substrate (1) with a probe dot matrix (3) and a cover plate (2) with at least two through-holes (4), where a hybrid chamber (5) is formed between the substrate (1) and the cover plate (2), at least two fluid channels (6) are interconnected respectively with the hybrid chamber (5) by the two through-holes (4), and a fluid control device is interconnected with the fluid channels (6). The biological chip hybridization system integrates hybridizing, cleaning and drying functions, uses power provided by the fluid control device as the drive force for promoting the liquid flow for automatically reciprocation flow in the fluid channels (6) and the chamber (5) to achieve a dynamic hybridization, thus improving the hybrid efficiency and uniformity, and achieving automatic control.