Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use
US9717730B2 · kind B2 · utility
1Cited by
46References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Feb 5, 2016 |
| Grant date | Aug 1, 2017 |
| Priority date | — |
| Expiry date | Feb 5, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides combinations comprising a) compound of formula I:or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.