Inhibitors of the renal outer medullary potassium channel

US9718808B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Dipshikha Biswas · Woodbridge, US
• Fa-Xiang Ding · Staten Island, US
• Shuzhi Dong · Plainsboro, US
• Xin Gu · Scotch Plains, US
• Jinlong Jiang · Scotch Plains, US
• Alexander Pasternak · Brookline, US
• Takao Suzuki · Shanghai, CN
• Joseph P. Vacca · Telford, US
• Shouning Xu · Shanghai, CN

Key dates

• Filing date: Jan 5, 2015
• Grant date: Aug 1, 2017
• Expiry date: Jan 5, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.