Tricyclic gyrase inhibitors

US9732083B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• Lawrence Livermore National Security, LLC · US

Inventors

• Daniel Bensen · Carlsbad, US
• Zhiyong Chen · San Diego, US
• John Finn · Mercerville, US
• Thanh To Lam · San Diego, US
• Suk Joong Lee · San Diego, US
• Xiaoming Li · Irvine, US
• Douglas Phillipson · Del Mar, US
• Leslie W. TARI · San Diego, US
• Michael Trzoss · San Diego, US
• Junhu Zhang · San Diego, US
• Felice C. Lightstone · Fremont, US
• Toan B. Nguyen · North Fair Oaks, US
• Sergio E. Wong · Tracy, US
• Paul A. Aristoff · Portage, US
• Michael E. Jung · Los Angeles, US

Key dates

• Filing date: Mar 14, 2012
• Grant date: Aug 15, 2017
• Expiry date: Dec 29, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.