Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]OXAZEPINES and methods for treating viral infections

US9732092B2 · kind B2 · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• Haolun Jin · Foster City, US
• Scott E. Lazerwith · Foster City, US
• Hyung-Jung Pyun · Fremont, US
• Elizabeth M. Bacon · Burlingame, US
• Philip Anthony Morganelli · Oakland, US
• Mingzhe Ji · Xi'an, CN

Key dates

• Filing date: Nov 11, 2016
• Grant date: Aug 15, 2017
• Expiry date: Nov 11, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.