Patent · US Active

2′-alkynyl substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

US9732111B2 · kind B2 · utility

1Cited by

2References

17Claims

0Family size

Assignee

Merck Sharp & Dohme LLC · US

Inventors

Frank Bennett · Piscataway, US
Yuhua Huang · Westfield, US
Lingyan Wang · East Brunswick Township, US
Stephane L. Bogen · Somerville, US
Angela Dawn Kerekes · Plainfield, US
Vinay M. Girijavallabhan · Woburn, US
Gabor Butora · Bound Brook, US
Quang T. Truong · Morganville, US
Ian Davies · Princeton, US
Ann E. Weber · Scotch Plains, US

Key dates

Filing date	Nov 14, 2013
Grant date	Aug 15, 2017
Priority date	—
Expiry date	Nov 14, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/7068
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to 2′-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2′-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.