Prefusion RSV F proteins and their use

US9738689B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Peter Kwong · Washington, US
• Barney Graham · Rockville, US
• Jason McLellan · Austin, US
• Man Chen · Shanghai, CN
• Michael Gordon Joyce · Washington, US
• Baoshan Zhang · Bethesda, US
• Tongqing Zhou · Boyds, US

Key dates

• Filing date: Mar 12, 2014
• Grant date: Aug 22, 2017
• Expiry date: Mar 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18534
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.