Biocatalytic transamination process
US9738915B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Dec 3, 2013 |
| Grant date | Aug 22, 2017 |
| Priority date | — |
| Expiry date | Dec 3, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y206/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I:employing dynamic kinetic resolution (DKR). The DKR process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors which may be useful for the treatment of cancer.
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