Patent · US Active

Method of establishing isogenic multi-xenograft model and the use thereof

US9743646B2 · kind B2 · utility

1Cited by

0References

10Claims

0Family size

Assignee

CROWN BIOSCIENCE, INC. (TAICANG) · CN

Inventors

Qian Shi · Chapel Hill, US
Yanmei Sun · Qingdao, CN

Key dates

Filing date	Apr 6, 2015
Grant date	Aug 29, 2017
Priority date	—
Expiry date	Apr 6, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01K2267/0331
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides an immuno-deficient animal useful as an animal model for a human disease associated with a first mutation of a target gene, wherein the animal comprises (a) a first human xenograft comprising the target gene comprising the first mutation; (b) a second human xenograft comprising the target gene but lacking the first mutation, wherein the first human xenograft and second human xenograft are isogenic. Also provided here are methods of producing the animal model and methods of using such animal model.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.