Inhibitors of the renal outer medullary potassium channel
US9751881B2 · kind B2 · utility
2Cited by
15References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 28, 2014 |
| Grant date | Sep 5, 2017 |
| Priority date | — |
| Expiry date | Aug 15, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.