Kallikrein inhibitors and anti-thrombolytic agents and uses thereof

US9757437B2 · kind B2 · utility

Assignee

• Dyax Corp. · US

Inventors

• Henry Blair · Boston, US
• Thomas Beck · Bad Soden am Taunus, DE
• Robert Charles Ladner · Urbana, US

Key dates

• Filing date: May 6, 2014
• Grant date: Sep 12, 2017
• Expiry date: May 6, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.