Therapeutic compounds and uses thereof

US9763922B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Constellation Pharmaceuticals, Inc. · US

Inventors

• Marc Adler · Orinda, US
• Brian K. Albrecht · Cambridge, US
• Sarah Bronner · South San Francisco, US
• Kevin X. Chen · Edison, US
• Alexandre Cote · Cambridge, US
• Terry Crawford · San Mateo, US
• Patrick Cyr · South San Francisco, US
• Jackson Egen · South San Francisco, US
• Steven Elliot Kauder · South San Francisco, US
• Kwong Wah Lai · Shanghai, CN
• Jiangpeng Liao · Shanghai, CN
• Steven R. Magnuson · South San Francisco, US
• Jeremy M. Murray · South San Francisco, US
• Richard Pastor · South San Francisco, US
• F. Anthony Romero · South San Francisco, US
• Alexander M. Taylor · Cambridge, US
• Vickie Hsiao-Wei Tsui · Burlingame, US
• Fei Wang · Beijing, CN
• Bing-Yan Zhu · South San Francisco, US

Key dates

• Filing date: Nov 25, 2015
• Grant date: Sep 19, 2017
• Expiry date: Nov 25, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) or formula (II):and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.