Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy

US9763956B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• The Brigham and Women's Hospital, Inc. · US
• The General Hospital Corporation · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Bradley E. Bernstein · Cambridge, US
• Jon Aster · Lexington, US
• James E. Bradner · Weston, US
• Birgit Knoechel · Brookline, US
• Christopher J. Ott · Glendale, US
• David E. Root · Santa Rosa, US

Key dates

• Filing date: Jun 19, 2013
• Grant date: Sep 19, 2017
• Expiry date: Jun 19, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to methods of treatment and diagnosis of subjects with cancer. In some aspects, the invention relates to methods of treatment and diagnosis of subjects with cancer, wherein the cancer is characterized by a Notch pathway activation mutation or by resistance to a Notch pathway inhibitor.