Phosphorous-linked oligomeric compounds and their use in gene modulation

US9771578B2 · kind B2 · utility

Assignee

• Ionis Pharmaceuticals, Inc. · US

Inventors

• Brenda F. Baker · Carlsbad, US
• Anne B. Eldrup · Newtown, US
• Muthiah Manoharan · Carlsbad, US
• Balkrishen Bhat · Carlsbad, US
• Richard H. Griffey · Vista, US
• Eric E. Swayze · Carlsbad, US
• Thazha P. Prakash · Carlsbad, US

Key dates

• Filing date: Aug 25, 2015
• Grant date: Sep 26, 2017
• Expiry date: Aug 25, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/346
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage.