Muthiah Manoharan
322Patents
56h-index
168Co-inventors
93Inventor score
Filing activity: Sep 3, 1993 → Oct 8, 2024
Most-cited inventions
| Patent | Title | Area | Cited by | Status |
|---|---|---|---|---|
| US5459255A | N-2 substituted purines | Chemistry; Metallurgy | 758 | Expired |
| US5587469A | Oligonucleotides containing N-2 substituted purines | Chemistry; Metallurgy | 574 | Expired |
| US5681941A | Substituted purines and oligonucleotide cross-linking | Chemistry; Metallurgy | 556 | Expired |
| US5578718A | Thiol-derivatized nucleosides | Chemistry; Metallurgy | 341 | Expired |
| US8158601B2 | Lipid formulation | Emerging Cross-Sectional Technologies | 293 | Active |
| US6335434B1 | Nucleosidic and non-nucleosidic folate conjugates | Chemistry; Metallurgy | 287 | Expired |
| US6210892A | Alteration of cellular behavior by antisense modulation of mRNA processing | Emerging Cross-Sectional Technologies | 245 | Expired |
| US9345780B2 | Site specific delivery of nucleic acids by combining targeting ligands with endosomolytic components | Chemistry; Metallurgy | 237 | Active |
| US6528631B1 | Oligonucleotide-folate conjugates | Chemistry; Metallurgy | 231 | Expired |
| US8106022B2 | Carbohydrate conjugates as delivery agents for oligonucleotides | Emerging Cross-Sectional Technologies | 229 | Active |
| US6153737A | Derivatized oligonucleotides having improved uptake and other properties | Chemistry; Metallurgy | 212 | Expired |
| US6147200A | 2'-O-acetamido modified monomers and oligomers | Chemistry; Metallurgy | 190 | Expired |
| US6600032B1 | 2′-O-aminoethyloxyethyl-modified oligonucleotides | Chemistry; Metallurgy | 184 | Expired |
| US6300319A | Targeted oligonucleotide conjugates | Chemistry; Metallurgy | 180 | Expired |
| US6656730B1 | Oligonucleotides conjugated to protein-binding drugs | Chemistry; Metallurgy | 176 | Expired |
| US8828956B2 | Carbohydrate conjugates as delivery agents for oligonucleotides | Emerging Cross-Sectional Technologies | 160 | Active |
| US6867294B1 | Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages | Chemistry; Metallurgy | 158 | Expired |
| US6242589A | Phosphorothioate oligonucleotides having modified internucleoside linkages | Chemistry; Metallurgy | 146 | Expired |
| US8450467B2 | Carbohydrate conjugates as delivery agents for oligonucleotides | Emerging Cross-Sectional Technologies | 145 | Active |
| US8642076B2 | Lipid containing formulations | Human Necessities | 138 | Active |
| US6127533A | 2'-O-aminooxy-modified oligonucleotides | Emerging Cross-Sectional Technologies | 129 | Expired |
| US6762169B1 | Ligand-conjugated oligomeric compounds | Chemistry; Metallurgy | 128 | Expired |
| US6395492B1 | Derivatized oligonucleotides having improved uptake and other properties | Chemistry; Metallurgy | 121 | Expired |
| US6271358A | RNA targeted 2'-modified oligonucleotides that are conformationally preorganized | Chemistry; Metallurgy | 119 | Expired |
| US7723509B2 | IRNA agents with biocleavable tethers | Chemistry; Metallurgy | 118 | Active |
Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.