Method for measuring ATR inhibition mediated increases in DNA damage
US9791456B2 · kind B2 · utility
17Cited by
50References
17Claims
0Family size
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Key dates
| Filing date | Feb 27, 2015 |
| Grant date | Oct 17, 2017 |
| Priority date | — |
| Expiry date | Feb 27, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2440/14
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.