Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

US9802917B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Nicole Buschmann · Basel, CH
• Robin Alec Fairhurst · Riehen, CH
• Pascal Furet · Basel, CH
• Bo Han · Shanghai, CN
• Thomas Knöpfel · Rheinfelden, CH
• Catherine Leblanc · Basel, CH
• Lv Liao · Shanghai, CN
• Robert Mah · Muttenz, CH
• Franck Mallet · Abbeville, FR
• Julie Martz · Colmar, FR
• Can Wang · Suzhou, CN
• Jing Xiong · Shanghai, CN
• Xianglin Zhao · Shanghai, CN

Key dates

• Filing date: Mar 18, 2016
• Grant date: Oct 31, 2017
• Expiry date: Mar 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, to a process of making said particles, to pharmaceutical compositions comprising said particles and to method of treating cancers using said pharmaceutical compositions.