Inhibitors of influenza viruses replication

US9808459B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Paul S. Charifson · Framingham, US
• Michael P. Clark · Maineville, US
• Upul K. Bandarage · Lexington, US
• Randy S. Bethiel · Bedford, US
• John J. Court · Littleton, US
• Hongbo Deng · Southborough, US
• Ioana Davies · Arlington, US
• John P. Duffy · Westborough, US
• Luc Farmer · Foxborough, US
• Huai Gao · Arlington, US
• Wenxin Gu · Concord, US
• Dylan H. Jacobs · Boston, US
• Joseph M. Kennedy · Walpole, US
• Mark Ledeboer · Acton, US
• Brian Ledford · Attleboro, US
• Francois Maltais · Somerville, US
• Emanuele Perola · Cambridge, US
• Tiansheng Wang · Concord, US
• M. Woods Wannamaker · Stow, US
• Randal Byrn · Wayland, US
• Yi Zhou · Lexington, US
• Chao Lin · Brookline, US
• Min Jiang · Lexington, US
• Steven Jones · West Chester, US
• Ursula A. Germann · Newton, US
• Francesco G. Salituro · Marlborough, US
• Ann Dak-Yee Kwong · Cambridge, US

Key dates

• Filing date: Oct 21, 2016
• Grant date: Nov 7, 2017
• Expiry date: Oct 21, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I):or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.