Targeting lipids
US9814777B2 · kind B2 · utility
7Cited by
5References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 2013 |
| Grant date | Nov 14, 2017 |
| Priority date | — |
| Expiry date | Oct 22, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides targeting lipids of structureL100-linker-L101 (CI),where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or —CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.