CRISPR-related methods and compositions with governing gRNAS

US9834791B2 · kind B2 · utility

Assignees

• Editas Medicine, Inc. · US
• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• University of Iowa Research Foundation · US

Inventors

• Feng Zhang · Cambridge, US
• Deborah Palestrant · Newton, US
• Beverly L. Davidson · Iowa City, US
• Jordi Mata-Fink · Baltimore, US
• Edgardo Rodriguez · Gainesville, US
• Alexis Borisy · Arlington, US

Key dates

• Filing date: Nov 7, 2014
• Grant date: Dec 5, 2017
• Expiry date: Nov 7, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.