Inhibitors of the renal outer medullary potassium channel

US9839629B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Shuzhi Dong · Plainsboro, US
• Alexander Pasternak · Brookline, US
• Xin Gu · Scotch Plains, US
• Qinghong Fu · Plainsboro, US
• Jinlong Jiang · Scotch Plains, US
• Fa-Xiang Ding · Staten Island, US
• Haifeng Tang · South San Francisco, US
• Reynalda K. DeJesus · East Brunswick Township, US
• Takao Suzuki · Shanghai, CN

Key dates

• Filing date: Dec 19, 2014
• Grant date: Dec 12, 2017
• Expiry date: Dec 19, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.