Compositions and methods for altering second messenger signaling

US9840533B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center · US
• Rutgers, the State University of New Jersey · US
• The Rockefeller University · US
• University of Bonn · DE

Inventors

• Dinshaw J. Patel · New York, US
• Thomas Tuschl · Oettingen, DE
• Manuel Ascano, Jr. · New York, US
• Yang-Chang Wu
• Yizhou Liu · New York, US
• Winfried Barchet · Bonn, DE
• Gunther Hartmann · Munich, DE
• Thomas Zillinger · Bonn, DE
• Roger A. Jones · New Brunswick, US
• Barbara L. Gaffney · Fryeburg, US
• Pu-Xian Gao · Coventry, US

Key dates

• Filing date: Apr 29, 2014
• Grant date: Dec 12, 2017
• Expiry date: Apr 29, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.