Patent · US Active

Trifluoromethyl alcohols as modulators of RORγt

US9850236B2 · kind B2 · utility

1Cited by

1References

43Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Steven Goldberg · Encinitas, US
Hariharan Venkatesan · San Diego, US
Virginia M. Tanis · Carlsbad, US
Olaf Kinzel · Heidelberg, DE
Christian Gege · Ehingen (Donau), DE
Christoph Steeneck · Dossenheim, DE
Gerald Kleymann · Bad Salzuflen, DE
Thomas Hoffmann · Santa Cruz, US
Anne Fourie · San Diego, US
Xiaohua Xue · San Diego, US

Key dates

Filing date	Oct 30, 2015
Grant date	Dec 26, 2017
Priority date	—
Expiry date	Oct 30, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D495/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention comprises compounds of Formula I.wherein:X, A1, A2, A3, A4, R1, R2, and R3 are defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.