Inhibitors of the renal outer medullary potassium channel

US9850245B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Alexander Pasternak · Brookline, US
• Fa-Xiang Ding · Staten Island, US
• Shuzhi Dong · Plainsboro, US
• Jinlong Jiang · Scotch Plains, US
• Haifeng Tang · South San Francisco, US
• Xin Gu · Scotch Plains, US
• Reynalda K. DeJesus · East Brunswick Township, US
• Jessica Frie · Harleysville, US
• Qinghong Fu · Plainsboro, US
• Takao Suzuki · Shanghai, CN
• Zhifa Pu · Shanghai, CN

Key dates

• Filing date: Oct 26, 2015
• Grant date: Dec 26, 2017
• Expiry date: Oct 26, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.