Vitamin D receptor/SMAD genomic circuit gates fibrotic response
US9872866B2 · kind B2 · utility
2Cited by
2References
5Claims
0Family size
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Key dates
| Filing date | Oct 23, 2015 |
| Grant date | Jan 23, 2018 |
| Priority date | — |
| Expiry date | Oct 23, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/085
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.