Covalent complex of von Willebrand Factor and factor VIII, compositions, and uses relating thereto

US9878017B2 · kind B2 · utility

Assignee

• CSL LIMITED · AU

Inventors

• Hubert Metzner · Marburg, DE
• Stefan Schulte · Marburg, DE
• Thomas Weimer · Gladenbach, DE

Key dates

• Filing date: Apr 22, 2014
• Grant date: Jan 30, 2018
• Expiry date: Apr 22, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a covalent complex of von Willebrand Factor (VWF) and Factor VIII, wherein the complex is modified such that it has an extended half-life in vivo. The invention further relates to a method of producing the complex, as well as the therapeutic or prophylactic use of the complex for treating or preventing bleeding events.