Rapid phenotypic diagnosis of pathogens and drug resistance using transcriptional expression signatures

US9885088B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• The General Hospital Corporation · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Deborah Hung · Cambridge, US
• James Gomez · Brookline, US
• Amy Barczak · Medford, US

Key dates

• Filing date: Feb 24, 2011
• Grant date: Feb 6, 2018
• Expiry date: Jun 2, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.