Inhibitors of the renal outer medullary potassium channel
US9951052B2 · kind B2 · utility
2Cited by
15References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 27, 2014 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Oct 27, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.