Thiazole-based inhibitors of scavenger receptor BI

US9951055B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Broad Institute, Inc. · US

Inventors

• Chris Dockendorff · Milwaukee, US
• Willmen Youngsaye · Boston, US
• Partha P. Nag · Somerville, US
• Timothy A. Lewis · Marlborough, US
• Sivaraman Dandapani · Malden, US
• Benito Munoz · San Diego, US
• Patrick Faloon · Cambridge, US
• Thomas Nieland · Somerville, US
• Monty Krieger · Needham, US
• Miao Yu · Quincy, US

Key dates

• Filing date: Oct 21, 2013
• Grant date: Apr 24, 2018
• Expiry date: Oct 21, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/048
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral infections.