A3 adenosine receptor agonists

US9963450B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Saint Louis University · US

Inventors

• Kenneth A. Jacobson · Silver Spring, US
• Dilip K. Tosh · Rockville, US
• Daniela Salvemini · Chesterfield, US

Key dates

• Filing date: Nov 20, 2014
• Grant date: May 8, 2018
• Expiry date: Nov 20, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of the formula (I) and (II) which are A3 adenosine receptor agonists, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein X, Y, Z, R2-R6, and R103-R106 are as defined in the specification. These compounds are selective to the A3 receptor, and are contemplated for use in the treatment or prevention of a number of diseases or conditions, for example, neuropathic pain.