Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3- B]pyrazin-2(1H)-one, a solid form there of and methods of their use

US9974786B2 · kind B2 · utility

Assignee

• Signal Pharmaceuticals, LLC · US

Inventors

• Marie Georges Beauchamps · Dover, US
• Antonio Christian Ferretti · Summit, US
• Juan Antonio Gamboa · New York, US
• Kevin J. Klopfer · Flemington, US
• William Edward Konnecke · Neshanic Station, US
• Matthew Michael Kreilein · Fryeburg, US
• Anil Menon · Bound Brook, US
• Amanda Nicole Miklos · Hoboken, US
• John F. Traverse · Lebanon, US

Key dates

• Filing date: Sep 19, 2017
• Grant date: May 22, 2018
• Expiry date: Sep 19, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologs and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.