Octapod iron oxide nanoparticles as high performance T2 contrast agents for magnetic resonance imaging

US9974868B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• XIAMEN UNIVERSITY · CN

Inventors

• Jinhao Gao · Xi'an, CN
• Xiaoyuan Chen · Acton, US
• Zenghuan Zhao · Chongqing, CN

Key dates

• Filing date: Jun 3, 2013
• Grant date: May 22, 2018
• Expiry date: Jun 3, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C01G49/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are nanoparticles comprising octapod iron oxide having eight trigonal bipyramidal arms and a method of preparing the same. The nanoparticles are prepared by heating a mixture of a ferric carboxylate, a carboxylic acid, a chloride salt, water, and a non-polar solvent, to a temperature above about 300° C. Also disclosed is a method of magnetic resonance imaging a tissue in a mammal, comprising use of the aforesaid nanoparticles.